Our laboratory is situated at the health sciences campus of Gasthuisberg in research building O&N1



Design SAVANT

Publications

2017:

van Vliet AR., Giordano F., Gerlo S., Segura I., Van Eygen S., Molenberghs G., Rocha S., Houcine A., Derua R., Verfaillie T., Vangindertael J., De Keersmaecker H., Waelkens E., Tavernier J., Hofkens J., Annaert W., Carmeliet P., Samali A., Mizuno H., Agostinis P. (2017). The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling. Molecular Cell

Garg, AD., Vandenberk, L., Fang, S., Fasche, T., Van Eygen, S., Maes, J., Van Woensel, M., Koks, C., Vanthillo, N., Graf, N., de Witte, P., Van Gool, S., Salven, P., Agostinis, P. (2017). Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing. Cell Death and Differentiation.

Demirsoy S., Martin S., Motamedi S., van Veen S., Holemans T., Van de Haute C., Jordanova A., Baekelandt V., Vangheluwe P., Agostinis P. (2017). ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function. Human Molecular Genetics.

2016:

van Vliet, A., Agostinis, P. (2016). When under pressure, get closer: PERKing up membrane contact sites during ER stress. Biochemical Society Transactions, 44 (2), 499-504.

Aaes, T., Kaczmarek, A., Delvaeye, T., De Craene, B., De Koker, S., Heyndrickx, L., Delrue, I., Taminau, J., Wiernicki, B., De Groote, P., Garg, A., Leybaert, L., Grooten, J., Bertrand, M., Agostinis, P., Berx, G., Declercq, W., Vandenabeele, P., Krysko, D. (2016). Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity. Cell Reports, 15 (2), art.nr. S2211-1247(16)30293-5.

Martin, S., van Veen, S., Holemans, T., Demirsoy, S., Van Den Haute, C., Baekelandt, V., Agostinis, P., Eggermont, J., Vangheluwe, P. (2016). Protection against mitochondrial and metal toxicity depends on functional lipid binding sites in ATP13A2. Parkinson's Disease, art.nr.10.1155/2016/9531917.

Galmes, R., Houcine, A., van Vliet, A., Agostinis, P., Jackson, C., Giordano, F. (2016). ORP5/ORP8 localize to Endoplasmic Reticulum-Mitochondria Contacts and are involved in Mitochondrial Function. EMBO Reports, art.nr. embr.201541108.

Vandenberk, L., Garg, A., Verschuere, T., Koks, C., Belmans, J., Beullens, M., Agostinis, P., De Vleeschouwer, S., Van Gool, S. (2016). Irradiation ofnecrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma. OncoImmunology, 5 (2), art.nr. e1083669.

Garg, A., De Ruysscher, D., Agostinis, P. (2016). Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian malignancies: A large-scale meta-analysis. OncoImmunology, 5, art.nr.e1069938.

Garg, A., Krysko, D., Vandenabeele, P., Agostinis, P. (2016). Extracellular ATP and P2X7 receptor exert context-specific immunogenic effects after immunogenic cancer cell death. Cell Death & Disease, 7, art.nr. e2097.

Garg, A., Vandenberk, L., Koks, C., Verschuere, T., Boon, L., Van Gool, S., Agostinis, P. (2016). Dendritic cell vaccines based on immunogenic cell death elicit danger signals and T cell-driven rejection of high-grade glioma. Science Translational Medicine.

Maes, H., Kuchnio, A., Carmeliet, P., Agostinis, P. (2016). Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature. Molecular & Cellular Oncology, 3 (1), art.nr. 10.4161/23723548.2014.970097.

2015:

van Vliet, A., Martin, S., Garg, A., Agostinis, P. (2015). The PERKs of damage-associated molecular patterns mediating cancer immunogenicity: From sensor to the plasma membrane and beyond. Seminars in Cancer Biology, 33, 74-85.

Monaco, G., Decrock, E., Arbel, N., van Vliet, A., La Rovere, R., De Smedt, H., Parys, J., Agostinis, P., Leybaert, L., Shoshan-Barmatz, V., Bultynck, G. (2015). The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria. Journal of Biological Chemistry, 290 (14), art.nr. jbc.M114.622514, 9150-9161.

Garg, A., Elsen, S., Krysko, D., Vandenabeele, P., de Witte, P., Agostinis, P. (2015). Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal. Oncotarget, 6 (29), art.nr.10.18632/oncotarget.4754, 26841-60.

Gijs, H., Willemarck, N., Vanderhoydonc, F., Khan, P., Dehairs, J., Derua, R., Waelkens, E., Taketomi, Y., Murakami, M., Agostinis, P., Annaert, W.,Swinnen, J. (2015). Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3. Molecular Biology of the Cell, 26 (12), 2321-2332.

Koks, C., Garg, A., Ehrhardt, M., Riva, M., Vandenberk, L., Boon, L., De Vleeschouwer, S., Agostinis, P., Graf, N., Van Gool, S. (2015). Newcastle diseasevirotherapy induces long-term survival and tumor-specific immune memory in orthotopic glioma through the induction of immunogenic cell death. International Journal of Cancer, 136 (5), art.nr. 10.1002/ijc.29202, E313-25.

Garg, A., Galluzzi, L., Apetoh, L., Baert, T., Birge, R., Bravo-San Pedro, J., Breckpot, K., Brough, D., Chaurio, R., Cirone, M., Coosemans, A., Coulie, P., De Ruysscher, D., Dini, L., de Witte, P., Dudek-Peric, A., Faggioni, A., Fucikova, J., Gaipl, U., Golab, J., Gougeon, M.,Hamblin, M., Hemminki, A., Herrmann, M., Hodge, J., Kepp, O., Kroemer, G., Krysko, D., Land, W., Madeo, F., Manfredi, A., Mattarollo, S., Maueroder, C., Merendino, N., Multhoff, G., Pabst, T., Ricci, J., Riganti, C., Romano, E., Rufo, N., Smyth, M., Sonnemann, J., Spisek, R.,Stagg, J., Vacchelli, E., Vandenabeele, P., Vandenberk, L., Van den Eynde, B., Van Gool, S., Velotti, F., Zitvogel, L., Agostinis, P. (2015). Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in Immunology, 6, art.nr. e588.

Garg, A., Dudek-Peric, A., Agostinis, P. (2015). Melphalan, Antimelanoma Immunity, and Inflammation-Response. Cancer Research, 75 (24), art.nr. 10.1158/0008-5472.CAN-15-2061, 5400-1.

Dudek-Perić, A., Gołąb, J., Garg, A., Agostinis, P. (2015). Melanoma targeting with the loco-regional chemotherapeutic, Melphalan: From cell death to immunotherapeutic efficacy. OncoImmunology, 4 (12), art.nr. e1054600.

Garg, A., Dudek-Peric, A., Romano, E., Agostinis, P. (2015). Immunogenic cell death. The International Journal of Developmental Biology, 59 (1-3), art.nr. 10.1387/ijdb.150061pa, 131-140.

Manshian, B., Munck, S., Agostinis, P., Himmelreich, U., Soenen, S. (2015). High content analysis at single cell level identifies different cellular responses dependent on nanomaterial concentrations. Scientific Reports, 5, art.nr. 10.1038/srep13890, 13890.

Martin, S., Dudek, A., Maes, H., Garg A., Gabrysiak, M., Demirsoy, S., Swinnen, J., Agostinis, P. (2015). Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells. Biochemical Pharmacology, 93 (3), 290-304.

Garg, A., Maes, H., Romano, E., Agostinis, P. (2015). Autophagy, a major adaptation pathway shaping cancer cell death and anticancer immunity responses following photodynamic therapy. Photochemical & Photobiological Sciences, 14 (8), art.nr. 10.1039/c4pp00466c, 1410-24.

Decuypere, J., Ceulemans, L., Agostinis, P., Monbaliu, D., Naesens, M., Pirenne, J., Jochmans, I. (2015). Autophagy and the Kidney: Implications for Ischemia-Reperfusion Injury and Therapy. American Journal of Kidney Diseases, 66 (4), art.nr. S0272-6386(15)00852-5, 699-709.

Dudek, A., Bomfim Ferreira, G., Muchowicz, A., Wouters, J., Prada, N., Martin, S., Kiviluoto, S., Winiarska, M., Boon, L., Mathieu, C., van den Oord, J., Stas, M., Gougeon, M., Golab, J., Garg, A., Agostinis, P. (2015). Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin. Cancer Research, 75 (8), 1603-1614.

Holemans, T., Sørensen, D., van Veen, S., Martin, S., Hermans, D., Kemmer, G., Van Den Haute, C., Baekelandt, V., Günther Pomorski, T.,Agostinis, P., Wuytack, F., Palmgren, M., Eggermont, J., Vangheluwe, P. (2015). A lipid switch unlocks Parkinson's disease-associated ATP13A2. Proceedings of the National Academy of Sciences of the United States of America, 112 (29), art.nr. 201508220, 9040-9045.

2014:

Maes, H., Kuchnio, A., Peric, A., Moens, S., Nys, K., De Bock, K., Quaegebeur, A., Schoors, S., Georgiadou, M., Wouters, J., Vinckier, S., Vankelecom, H., Garmyn, M., Vion, A., Boulanger, C., Gerhardt, H., Dejana, E., Dewerchin, M., Ghesquière, B., Annaert, W., Agostinis, P.,Carmeliet, P. (2014). Tumor vessel normalization by chloroquine independent of autophagy. Cancer Cell, 26 (2), 190-206.

Adkins, I., Fucikova, J., Garg, A., Agostinis, P., Špíšek, R. (2014). Physical modalities inducing immunogenic tumor cell death for cancer immunotherapy. OncoImmunology, 3 (12), art.nr. e968434.

Rubio, N., Verrax, J., Dewaele, M., Verfaillie, T., Johansen, T., Piette, J., Agostinis, P. (2014). p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. Free Radical Biology & Medicine, 67, art.nr. S0891-5849(13)01499-8, 292-303.

Maes, H., Kuchnio Anna, A., Carmeliet, P., Agostinis, P. (2014). How to teach an old dog new tricks: autophagy-independent action of chloroquine on the tumor vasculature. Autophagy, 10 (11), art.nr. 10.4161/auto.36259, 2082-2084.

Garg, A., Agostinis, P. (2014). ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses. Photochemical & Photobiological Sciences, 13 (3), art.nr. 10.1039/c3pp50333j, 474-87.

Barrette, K., Van Kelst, S., Wouters, J., Marasigan, V., Fieuws, S., Agostinis, P., van den Oord, J., Garmyn, M. (2014). Epithelial-mesenchymal transition during invasion of cutaneous squamous cell carcinoma is paralleled by AKT activation. British Journal of Dermatology, 171(5), art.nr. 10.1111/bjd.12967, 1014-1021.

Maes, H., Martin, S., Verfaillie, T., Agostinis, P. (2014). Dynamic interplay between autophagic flux and Akt during melanoma progression in vitro. Experimental Dermatology, 23 (2), art.nr. 10.1111/exd.12298, 101-6.

Garg, A., Martin, S., Golab, J., Agostinis, P. (2014). Danger signalling during cancer cell death: origins, plasticity and regulation. Cell Death and Differentiation, 21 (1), art.nr. 10.1038/cdd.2013.48, 26-38.

Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., Bracci, L., Breckpot, K., Brough, D., Buque, A., Castro, M., Cirone, M., Colombo, M., Cremer, I., Demaria, S., Dini, L., Eliopoulos, A., Faggioni, A.,Formenti, S., Fucikova, J., Gabriele, L., Gaipl, U., Galon, J., Garg, A., Ghiringhelli, F., Giese, N., Guo, Z., Hemminki, A., Herrmann, M., Hodge, J., Holdenrieder, S., Honeychurch, J., Hu, H., Huang, X., Illidge, T., Kono, K., Korbelik, M., Krysko, D., Loi, S., Lowenstein, P.,Lugli, E., Ma, Y., Madeo, F., Manfredi, A., Martins, I., Mavilio, D., Menger, L., Merendino, N., Michaud, M., Mignot, G., Mossman, K., Multhoff, G., Oehler, R., Palombo, F., Panaretakis, T., Pol, J., Proietti, E., Ricci, J., Riganti, C., Rovere-Querini, P., Rubartelli, A., Sistigu, A.,Smyth, M., Sonnemann, J., Spisek, R., Stagg, J., Sukkurwala, A., Tartour, E., Thorburn, A., Thorne, S., Vandenabeele, P., Velotti, F., Workenhe, S., Yang, H., Zong, W., Zitvogel, L., Kroemer, G., Galluzzi, L. (2014). Consensus guidelines for the detection of immunogenic cell death. OncoImmunology, 3 (9), 12472-124508.

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J., Buque, A., Senovilla, L., Baracco, E., Bloy, N., Castoldi, F., Abastado, J., Agostinis, P., Apte, R., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Cerundolo, V., Clayton, A.,Colombo, M., Coussens, L., Dhodapkar, M., Eggermont, A., Fearon, D., Fridman, W., Fucikova, J., Gabrilovich, D., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jaeger, D., Kalinski, P., Kaerre, K., Kepp, O., Kiessling, R.,Kirkwood, J., Klein, E., Knuth, A., Lewis, C., Liblau, R., Lotze, M., Lugli, E., Mach, J., Mattei, F., Mavilio, D., Melero, I., Melief, C., Mittendorf, E., Moretta, L., Odunsi, A., Okada, H., Palucka, A., Peter, M., Pienta, K., Porgador, A., Prendergast, G., Rabinovich, G., Restifo, N.,Rizvi, N., Sautes-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M., Speiser, D., Spisek, R., Srivastava, P., Talmadge, J., Tartour, E., Van der Burg, S., Van den Eynde, B., Vile, R.,Wagner, H., Weber, J., Whiteside, T., Wolchok, J., Zitvogel, L., Zou, W.,Kroemer, G. (2014). Classification of current anticancer immunotherapies. Oncotarget, 5 (24), 2014, 12472-12508.

Maes, H., Van Eygen, S., Krysko, D., Vandenabeele, P., Nys, K., Rillaerts, K., Garg, A., Verfaillie, T., Agostinis, P. (2014). BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton. Cell Death & Disease, 5, art.nr. e1127.

Agostinis, P., De Milito, A., Esclatine, A., Simon, H. (2014). Autophagy researchers. Autophagy, 10 (9), 1483-1486.

Maes, H., Agostinis, P. (2014). Autophagy and mitophagy interplay in melanoma progression. Mitochondrion, 19, 58-68.

Dejeans, N., Manié, S., Hetz, C., Bard, F., Hupp, T., Agostinis, P., Samali, A., Chevet, E. (2014). Addicted to secrete - novel concepts and targets in cancer therapy. Trends in Molecular Medicine, 20 (5), art.nr. S1471-4914(13)00213-X, 242-50.

2013:

Wouters, J., Stas, M., Gremeaux, L., Govaere, O., Van den Broeck, A., Maes, H., Agostinis, P., Roskams, T., van den Oord, J., Vankelecom, H. (2013). The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis. PLoS One, 8 (10), art.nr. 10.1371/journal.pone.0076550, e76550.

Verfaillie, T., Garg, A., Agostinis, P. (2013). Targeting ER stress induced apoptosis and inflammation in cancer. Cancer Letters, 332, 249-264.

Garg, A., Dudek, A., Ferreira, G., Verfaillie, T., Vandenabeele, P., Krysko, D., Mathieu, C., Agostinis, P. (2013). ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. Autophagy, 9 (9), 1292-307.

Verfaillie, T., van Vliet, A., Garg, A., Dewaele, M., Rubio, N., Gupta, S., de Witte, P., Samali, A., Agostinis, P. (2013). Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. Biochemical and Biophysical Research Communications, 438 (3), art.nr. 10.1016/j.bbrc.2013.07.107, 500-6.

Wang, B., Van Veldhoven, P., Brees, C., Rubio, N., Nordgren, M., Ivashchenko en Apanasets, O., Kunze, M., Baes, M., Agostinis, P., Fransen, M. (2013). Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells. Free Radical Biology & Medicine, 65, 882-894.

Dudek, A., Garg, A., Krysko, D., De Ruysscher, D., Agostinis, P. (2013). Inducers of immunogenic cancer cell death. Cytokine & Growth Factor Reviews, 24 (4), art.nr. S1359-6101(13)00006-3, 319-33.

Dudek, A., Martin, S., Garg, A., Agostinis, P. (2013). Immature, Semi-Mature, and Fully Mature Dendritic Cells: Toward a DC-Cancer Cells Interface That Augments Anticancer Immunity. Frontiers in Immunology, 11 (4), art.nr. 10.3389/fimmu.2013.00438, 438.

Hoefkens, E., Nys, K., John, J., Van Steen, K., Arijs, I., Van der Goten, J., Van Assche, G., Agostinis, P., Rutgeerts, P., Vermeire, S., Cleynen, I. (2013). Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress. Autophagy, 9 (12), art.nr. 10.4161/auto.26337, 2046-55.

Garg, A., Dudek, A., Agostinis, P. (2013). Cancer immunogenicity, danger signals, and DAMPs: What, when, and how?. BioFactors, 39 (4), art.nr. 10.1002/biof.1125, 355-67.

Garg, A., Dudek, A., Agostinis, P. (2013). Calreticulin surface exposure is abrogated in cells lacking, chaperone-mediated autophagy-essential gene, LAMP2A. Cell Death & Disease, 4, art.nr. 10.1038/cddis.2013.372, e826.

Maes, H., Rubio, N., Garg, A., Agostinis, P. (2013). Autophagy: shaping the tumor microenvironment and therapeutic response. Trends in Molecular Medicine, 19 (7), art.nr. 10.1016/j.molmed.2013.04.005, 428-46.

Nys, K., Agostinis, P., Vermeire, S. (2013). Autophagy: a new target or an old strategy for the treatment of Crohn's disease?. Nature Reviews. Gastroenterology & Hepatology, 10 (7), art.nr. 10.1038/nrgastro.2013.66, 395-401.

Garg, A., Dudek, A., Agostinis, P. (2013). Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity. OncoImmunology, 2 (10), e26260-e26260.

2012:

Lebeer, S., Claes, I., Balog, C., Schoofs, G., Verhoeven, T., Nys, K., von Ossowski, I., de Vos, W., Tytgat, H., Agostinis, P., Palva, A., Van Damme, E.,Deelder, A., De Keersmaecker, S., Wuhrer, M., Vanderleyden, J. (2012). The major secreted protein Msp1/p75 is O-glycosylated in Lactobacillus rhamnosus GG. Microbial Cell Factories, 11, art.nr. 15, 15.

Garg, A., Krysko, D., Vandenabeele, P., Agostinis, P. (2012). The emergence of phox-ER stress induced immunogenic apoptosis. OncoImmunology, 1 (5), 786-788.

Rubio Romero, N., Coupienne, I., Di Valentin, E., Heirman, I., Grooten, J., Piette, J., Agostinis, P. (2012). Spatiotemporal autophagic degradation of oxidatively damaged organelles after photodynamic stress is amplified by mitochondrial reactive oxygen species. Autophagy, 8 (9),1312-1324.

Nys, K., Maes, H., Andrei, G., Snoeck, R., Garmyn, M., Agostinis, P. (2012). Skin mild hypoxia enhances killing of UVB-damaged keratinocytes through reactive oxygen species-mediated apoptosis requiring Noxa and Bim. Free Radical Biology & Medicine, 52 (6), 1111-1120.

Gupta, S., Read, D., Deepti, A., Cawley, K., Gupta, A., Oommen, D., Verfaillie, T., Matus, S., Smith, M., Mott, J., Agostinis, P., Hetz, C., Samali, A. (2012). Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis. Cell Death & Disease, 3, art.nr. 10.1038/cddis.2012.74, e333.

Verfaillie, T., Rubio Romero, N., Garg, A., Bultynck, G., Rizzuto, R., Siviero, R., Decuypere, J., Piette, J., Linehan, C., Gupta, S., Samali, A.,Agostinis, P. (2012). PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell death and differentiation, 19 (11), 1880-91.

Krysko, D., Garg, A., Kaczmarek, A., Krysko, O., Agostinis, P., Vandenabeele, P. (2012). Immunogenic cell death and DAMPs in cancer therapy. Nature Reviews. Cancer, 12 (12), art.nr. 10.1038/nrc3380, 860-75.

Garg, A., Krysko, D., Vandenabeele, P., Agostinis, P. (2012). Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin. Cancer Immunology, Immunotherapy, 61 (2), 215-21.

Garg, A., Kaczmarek, A., Krysko, O., Vandenabeele, P., Krysko, D., Agostinis, P. (2012). ER stress induced inflammation: Does it aid/impede disease progression. Trends in Molecular Medicine, 18 (10), 589-598.

Nys, K., Agostinis, P. (2012). Bcl-2 family members: Essential players in skin cancer. Cancer Letters, 320 (1), 1-13.

Wirawan, E., Berghe, T., Lippens, S., Agostinis, P., Vandenabeele, P. (2012). Autophagy: for better or for worse. Cell Research, 22 (1), art.nr. 10.1038/cr.2011.152, 43-61.

Verschooten, L., Barrette, K., Van Kelst, S., Rubio Romero, N., Proby, C., De Vos, R., Agostinis, P., Garmyn, M. (2012). Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid Luteolin in metastatic squamous cell carcinoma cells. PLoS One, 7(10), art.nr. e48264.

Garg, A., Krysko, D., Verfaillie, T., Kaczmarek, A., Ferreira, G., Marysael, T., Rubio, N., Firczuk, M., Mathieu, C., Roebroek, A., Annaert, W., Golab, J.,de Witte, P., Vandenabeele, P., Agostinis, P. (2012). A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death. EMBO Journal, 31 (5), 1062-1079.

2011:

Nys, K., Maes, H., Dudek, A., Agostinis, P. (2011). Uncovering the role of Hypoxia inducible factor-1alpha in skin carcinogenesis. Biochimica et Biophysica Acta. Reviews on Cancer, 1816 (1), 1-12.

Agostinis, P., Berg, K., Cengel, K., Foster, T., Girotti, A., Gollnick, S., Hahn, S., Hamblin, M., Juzeniene, A., Kessel, D., Korbelik, M., Moan, J., Mroz, P., Nowis, D., Piette, J., Wilson, B., Golab, J. (2011). Photodynamic therapy of cancer: An update. CA, 61 (4), 250-281.

Coupienne, I., Bontems, S., Dewaele, M., Rubio, N., Habraken, Y., Fulda, S., Agostinis, P., Piette, J. (2011). NF-kappaB inhibition improves the sensitivity of human glioblastoma cells to 5-aminolevulinic acid-based photodynamic therapy. Biochemical Pharmacology, 81 (5), 606-616.

Decuypere, J., Welkenhuyzen, K., Luyten, T., Ponsaerts, R., Dewaele, M., Molgó, J., Agostinis, P., Missiaen, L., De Smedt, H., Parys, J., Bultynck, G. (2011). Ins(1,4,5)P-3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated. Autophagy, 7 (12), art.nr.22082873, 1472-1489.

Krysko, D., Agostinis, P., Krysko, O., Garg, A., Bachert, C., Lambrecht, B., Vandenabeele, P. (2011). Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends in Immunology, 32 (4), 157-164.

Garg, A., Krysko, D., Vandenabeele, P., Agostinis, P. (2011). DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown. Photochemical & Photobiological Sciences, 10 (5), 670-680.

Dewaele, M., Martinet, W., Rubio Romero, N., Verfaillie, T., de Witte, P., Piette, J., Agostinis, P. (2011). Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage. Journal of Cellular and Molecular Medicine, 15, 1402-1414.

Coupienne, I., Fettweis, G., Rubio, N., Agostinis, P., Piette, J. (2011). 5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma. Photochemical & Photobiological Sciences, 10 (12), 1868-1878.

Declercq, W., Agostinis, P., Vandenabeele, P. (2011). 18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010. Cell Death and Differentiation, 18 (9), 1540-1542.

2010:

Verschooten, L., Smaers, K., Van Kelst, S., Proby, C., Maes, D., Declercq, L., Agostinis, P., Garmyn, M. (2010). The Flavonoid Luteolin Increases the Resistance of Normal, but Not Malignant Keratinocytes, Against UVB-Induced Apoptosis. Journal of Investigative Dermatology,130 (9), 2277-2285.

Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, P., Haslam, S., Dell, A., Penninger, J., Erneux, C., Piette, J., Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia, 24 (4), 821-32.

Dewaele, M., Maes, H., Agostinis, P. (2010). ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy, 6 (7), 838-54.

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Where to find us:

Useful links to reach Leuven:
Official tourist page: Link
Transfer by train: Leuven is about 30min away by train from Brussels airport. Trains to Leuven leave Brussels airport approx. every 15min.
To reach Campus Gasthuisberg see this link

Contact:

To contact the lab, please send an email to: 
Patrizia Agostinis
Cell Death Research and Therapy Lab, Department of Cellular & Molecular Medicine
Faculty of Medicine
Campus Gasthuisberg, O&N I Herestraat 49 - bus 802
3000 Leuven, Belgium
Tel 003216330650,
Email: 
patrizia.agostinis@kuleuven.be